The origin of the small saphenous vein (SSV) is where the dorsal vein from the fifth digit (smallest toe) merges with the dorsal venous arch of the foot, which attaches to the great saphenous vein (GSV).

From its origin, it courses around the lateral aspect of the foot (inferior and posterior to the lateral malleolus) and runs along the posterior aspect of the leg (with the sural nerve), where it passes between the heads of the gastrocnemius muscle.

[1] Usually, it drains into the popliteal vein, at or above the level of the knee joint.

[2] Sometimes, it does not make contact with the popliteal vein, but goes up to drain in the GSV at a variable level.

[4] The small saphenous vein may be harvested for transplant to elsewhere in the body, such as in coronary artery bypass surgery.