The series recounts the early adventures of Kryptonian Clark Kent as he adjusts to life in the fictional town of Smallville, Kansas, during the years before he becomes Superman.

Regular cast members during season seven include Tom Welling, Michael Rosenbaum, Kristin Kreuk, Allison Mack, Erica Durance, Aaron Ashmore, Laura Vandervoort, and John Glover.

In addition to bringing in new regular cast members this season, the Smallville team brought in familiar faces from the Superman media history, old villains from the show's past, as well as new DC Comics characters Kara Zor-El and Dinah Lance.

This season focuses on Clark Kent meeting his biological cousin Kara (Vandervoort), and teaching her how to control her abilities in public; Lana Lang's behavior toward her friends, Lex Luthor, and after it is discovered that she faked her own death; Chloe coming to terms with her newly discovered kryptonite-induced ability; and the secret of the Daily Planet's new editor Grant Gabriel.

The strike also forced The CW to push back airdates on several episodes, and cost Allison Mack her directorial debut.

A prolonged strike would have forced television shows to end their seasons early, because no scripts could be written until a settlement had been reached.

[24] The strike pushed back Smallville's scheduling, as the episode "Siren", which was originally intended to be aired on January 10, 2008,[25] was moved to a February 7 airdate.

[36] Marc McClure, who portrayed Jimmy Olsen in all of the Superman films as well as in Supergirl, was brought in to play a Kryptonian scientist named Dax-Ur for the episode "Persona".

Black Canary was portrayed by Canadian actress Alaina Huffman, and the episode featured the return of Justin Hartley as the Green Arrow.

The CW began this tie-in campaign with the March 13 episode "Hero", where Pete develops superhuman elasticity after chewing some kryptonite-infused Stride gum.

[4][43] "Bizarro" and "Cure" were also the highest-rated episodes of the season, both being seen by 5.18 million viewers and scoring a 1.8 in the Nielsen rating in the 2 year old and up demographic.