The Smith–Lyon Farmhouse is a historic farm at 400 N. Woodstock Road in Southbridge, Massachusetts.

It is an unusual example of a well-preserved rural Greek Revival house in Southbridge.

The gable-end front facade features full-length sidelights around the door, pilastered corner trim, a pedimented gable, and a full-width porch with Doric columns.

[2] The house was listed on the National Register of Historic Places in 1989.

This article about a National Register of Historic Places listing in Worcester County, Massachusetts is a stub.