Smithfield is a plantation house in Blacksburg, Virginia, built from 1772 to 1774 by Col. William Preston to be his residence and the headquarters of his farm.

The plantation site was part of 120,000 acres originally granted to James Patton by the British Crown.

[5] The property then passed to his wife, Susanna Smith Preston, who lived there until her death forty years later.

It was also the birthplace and home of his son, William Ballard Preston, who worked with Abraham Lincoln in the 1840s in Congress as part of a group of legislators known as "The Young Indians" and later authored Virginia's Articles of Secession in 1861.

The rooms of the house are furnished with eighteenth and nineteenth century Decorative arts furniture, portraits and other items, while the basement level Museum contains a variety of artifacts found on-site, including Native American relics.