Smithfield Historic District is a national historic district located at Smithfield, Isle of Wight County, Virginia.

It encompasses 289 contributing buildings and 2 contributing structures in the historic downtown and surrounding residential areas of Smithfield.

There are 211 houses, 37 commercial buildings, 1 warehouse, 4 churches, 10 barns, 1 smokehouse, 23 garages, 1 farm office, 1 colonial kitchen, and 2 corncrib structures.

Located in the district and separately listed are the Old Isle of Wight Courthouse, Smithfield Inn, Windsor Castle Farm, and P. D. Gwaltney Jr.

[3][4] It was listed on the National Register of Historic Places in 1973.