It contains the line "O-oh smokestack lightnin', shinin', just like gold, oh don't you hear me cryin'", similar to the Mississippi Sheiks' lyric "A-ah, smokestack lightnin', that bell shine just like gold, now don't you hear me talkin'".

[1] The song takes the form of "a propulsive, one-chord vamp, nominally in E major but with the flatted blue notes that make it sound like E minor", and lyrically it is "a pastiche of ancient blues lines and train references, timeless and evocative".

[10] As the UK experienced an R&B boom in the early 1960s, British R&B groups regularly covered "Smokestack Lightning" in their live acts.

"[8] In 1999, the song received a Grammy Hall of Fame Award, honoring its lasting historical significance.

[16] Janovitz also identifies "Smokestack Lightning" as a blues standard "open to varied interpretation, covered by artists ranging from the Yardbirds to Soundgarden, all stamping their personal imprint on the song".