Lewis DeWitt "Snake" Wiltse (December 5, 1871 – August 25, 1928) was a pitcher in Major League Baseball.

His younger brother was fellow major league pitcher George "Hooks" Wiltse.

[1] Nicknamed "Snake" because of his highly contorted pitching motion, he started playing semi-pro baseball in 1894[2] and then began his professional career in 1899 with the Toledo Mud Hens.

[1] On August 10, he made history, hitting two doubles and two triples for 10 total bases, which set an MLB record for pitchers.

[1] His overall major league pitching record was 29 wins and 31 losses in 62 games, with an earned run average of 4.59.