[3] In addition to Cobra Starship vocalist Gabe Saporta, the song features William Beckett of The Academy Is..., Travie McCoy of Gym Class Heroes, and Maja Ivarsson of The Sounds.

"[5]Saporta began writing "Snakes on a Plane (Bring It)" when Pete Wentz and Jonathan Daniel of Crush Music approached him and thought that the song "would be perfect" for the soundtrack.

"[8] The video, directed by Lex Halaby,[5] shows McCoy, Ivarsson, Saporta and Beckett walking through Honolulu International Airport, acting as if they were villains hired by Eddie Kim (the antagonist of Snakes on a Plane) sneaking snakes on board in their suitcase and guitar case.

Pete Wentz of Fall Out Boy makes a cameo appearance[7] (at 1:46), talking on a payphone nervously as the band members pass ominously.

Samuel L. Jackson (who plays Neville Flynn, the main protagonist of the movie) also makes a cameo appearance, lowering his shades and eyeing the band members as they pass, unaware of the true contents inside their cases before returning to his 100 Bullets comic.