The song's lyrics discuss the cancer diagnoses of Minogue's sister Kylie and an unnamed friend.

It entered the top forty in Australia, Ireland and the UK and became Minogue's tenth consecutive Upfront Club Chart number one.

The song's music video, directed by Phil Griffin, features Minogue in a variety of high pressure situations.

In 2005, Minogue began writing and recording material with longtime collaborator Terry Ronald and British dance group LMC.

During one of their sessions, they penned "So Under Pressure", which was inspired by the cancer diagnoses of her sister Kylie as well as that of an unnamed friend.

Growing up it never occurred to me that it wasn’t a girly thing to ride a bike, covered in mud holding frogs and collecting lizards!".

Scenes of Minogue and her three dancers walking a catwalk, posing for photographs and dancing are intercut throughout the music video.