[2] She then joined the LPGA of Korea, winning the first event she played, the Sports Seoul Open.

Ryu picked up her second career LPGA Tour win in 2012 at the Jamie Farr Toledo Classic.

[3] On 23 June 2013, Ryu lost in a sudden-death playoff at the Walmart NW Arkansas Championship to fellow South Korean Inbee Park.

Park made birdie on the first extra hole to take the victory after Ryu could only make par.

On 2 April 2017, Ryu won her second major championship at the ANA Inspiration with a sudden-death playoff victory over Lexi Thompson.

On 25 June 2017, Ryu won the Walmart NW Arkansas Championship and became the number one golfer in the Women's World Golf Rankings.