[2] He was the campaign manager for the African Party for the Independence of Guinea and Cape Verde (PAIGC) during the March 2004 parliamentary election,[2][3] in which PAIGC won a plurality of seats; following the election, he became Minister of External Affairs on May 12, 2004, as part of the government of the new Prime Minister, Carlos Gomes Júnior.
[2][4] Carlos Gomes's government was dismissed in November 2005, and Sambu was replaced as Foreign Minister.
[7] On June 7, 2013, he took over the Ministry of Economy and Regional Integration, one of the key branches of the transitional government of Prime Minister Rui Duarte de Barros, leaving office in 2014 to contest the legislative elections.
He was re-elected as a deputy in the general elections in Guinea-Bissau in 2014, having become one of 15 dissident MPs of the PAIGC, which formed the independent wing of the party.
[8] He has been an MP for nearly 20 years, where he held the positions of the Chairman of the Permanent Commission for Agriculture, Natural Resources, Environment, Fisheries and Tourism; President of the Technical Commission of the Elaboration of the Law of the Earth between other functions of relief inside and outside Guinean State.