Sofía Álvarez Vignoli (10 August 1899 – 12 May 1986) was a Uruguayan jurist and briefly First Lady of Uruguay, who was active in the struggle to achieve Women's Suffrage.

On completion of the course, they married and subsequently had two children Julio Alberto (1938–1975) and María Adelina Demicheli Alvarez.

Her husband Dr. Alberto Demicheli served as interior minister in the 1930s and was President of Uruguay as an interim measure in 1976.

Álvarez Vignoli de Demicheli headed the group which supported the conservative dictator to whom prestigious feminists, such as sisters Paulina y Luisa Luisi, were opposed.

At the same time, Julia Arévalo de Roche and Magdalena Antonelli Moreno were elected deputies.