Its studios are based in Soho, London, and in Rockefeller Center in New York City.

In December 2020, Soho Radio launched in New York, broadcasting live from Rockefeller Center.

Soho Radio has over 250 resident presenters covering all genres, including Primal Scream's Simone Marie, dub legend Dennis Bovell, Groove Armada's Tom Findlay, Unkle's James Lavelle, Jim Sclavunos of Nick Cave & The Bad Seeds, Metronomy's Anna Prior, DJ Norman Jay MBE and Anton Newcombe of The Brian Jonestown massacre.

[2] Notable hosts and guests include: Soho Radio host Vinyl Sessions, with artists performing two tracks live as they cut the session direct to acetate.

The Soho Radio Vinyl Session with Paul Weller raised £2500 for the charity Shelter.