The aircraft involved, a Saab 340, was operating Sol Líneas Aéreas' scheduled domestic service from Neuquén to Comodoro Rivadavia.

After completing uneventfully the first three segments, the Saab 340 took off from Presidente Perón International Airport in Neuquén at 20:05 for its final leg.

Control of the aircraft was lost shortly after, and the Saab 340 impacted the ground in a remote region of the Río Negro Province, between the villages of Los Menucos and Prahuaniyeu.

A mayday call was received by the crew of a business jet flying in the area shortly before Flight 5428 was lost.

Local people around 2 kilometres (1.2 mi; 1.1 nmi) away from the crash site saw an airplane flying extremely low.

[13] One of the passengers used a passport for identification purposes at the check-in desk, while the rest used Argentine Documento Nacional de Identidad (DNI) identity documents.

In September 2011, a preliminary report was issued which stated that the cause of the accident was a stall due to severe airframe icing and subsequent loss of control.