[1] He represents the electoral district of Jean-Lesage as a member of Québec solidaire.

Following his win in the 2022 provincial election, he was chosen as its critic for Sovereignty, Canadian Relations, Democratic Institutions, Access to Information and Protection of Personal Information, and the Family.

He was previously the leader of Option nationale, a Quebec sovereigntist political party, from 2013 to 2018.

[2] A candidate for the party in the 2012 provincial election, Zanetti won the party's leadership on October 26, 2013, winning 67 per cent of the leadership vote against musician and activist Nic Payne.

[3] In September 2014, Zanetti published a video on YouTube encouraging voters in the Scottish independence referendum to vote yes.