In the early 1930s, SCADTA based its main hub at Veranillo Airport which was a seaplane port on the Magdalena River which had been operating since 1919, the year of the airline's inception.
The airline operated several Fokker Universals and Sikorsky S-38s from the main terminal at the seaplane port to many different parts of Colombia.
Since 1929, it had also been an important stopover point for Pan American World Airways, which operated Sikorsky S-42s to parts of Panama and Venezuela.
DC-3s had been gaining in popularity at the time, and in 1939 SCADTA acquired and began operating the type.
Pan Am also began flying DC-3s to the airport, and by the beginning of 1940, it became the first major air hub in the country.