[1] In addition to her own material, Mohapatra has recorded remixes of songs by David Bowie, with "Let's Dance", and INXS, with "Afterglow", with the latter proving particularly successful.

One of her most famous jingles was for Tata Salt – "Kal Ka Bharat Hai" & the campaign for Unilever's Close Up has a section of her song "Paas Aao Na," which has been recorded in several languages and aired across 13 countries for four consecutive years.

In 2007, she released her debut album, Sona, on Sony Records, which sought to explore the diverse styles of rock, rhythm and blues, Flamenco, Hindustani, Baul and Romani music.

Sona Mohapatra came to mainstream prominence with the trendbreaking talk show Satyamev Jayate with Aamir Khan, in which she frequently appeared as a lead singer and performer.

The song "Mujhe Kya Bechega Rupaiya," sung by Mohapatra, was composed by Ram Sampath and was aired on the third episode of Satyamev Jayate based on celebrating women's freedom.

[11][12] In 2019, Mohapatra received a death threat after she lashed out at Salman Khan for constantly taking digs at Priyanka Chopra for leaving Bharat.