Sopetrán is a municipality of Colombia, located in the subregion west of the state of Antioquia.

As of 2007[update], Sopetrán was one of three municipalities along the Route of the Sun in western Antioquia[citation needed], along with the municipalities of San Jerónimo and Santa Fe de Antioquia, with which Sopetrán shares much of its history[citation needed].

Since the opening of the West Fernando Gomez Martinez Tunnel in 2006, tourism in the region has tripled[citation needed].

On February 22, 1616, the municipality of Sopetrán was officially established by Francisco Herrera and Campuzano, a native of Alcala de Henares in Spain.

The latter caught the Spaniards' attention, who had been transporting salt from the sea for domestic use and to feed the newly imported cattle.