Her parents provided her with a comprehensive and thorough education and started marriage negotiations when she was young.

She married as a 16-year-old on 20 October 1577 in Wolgast to Duke Ernst Ludwig of Pommern-Wolgast (1545–1592).

[6] Between 1597 and 1601, she accompanied her son, who was introduced into the business of government by his guardian and regent Duke Bogislaw XIII.

During her husband's lifetime, Sophia Hedwig had rebuilt the castle at Loitz as a renaissance château.

Some of her contributions to the church, however, are still there, among them the ducal seats, a double portrait of herself and her husband, and numerous coats of arms of their ancestors.

[9] Sophia Hedwig was described as interested in economic processes, but also as wasteful and overbearing.