In 2006, she played her first television role as the daughter of Barbara Rudnik and Henry Hübchen with TV director Sigi Rothemund in the ARD crime series Commissario Laurenti.

In 2012, Thomalla appeared in the ensemble of the comedy series Die Dreisten Drei on Sat.1, alongside Oliver Beerhenke and Mirco Nontschew.

[3] In the October 2015 edition of Playboy, Thomalla was portrayed together with her mother and 23 other women, including Christine Theiss, Tina Ruland, Regina Halmich, Katarina Witt, Charlotte Engelhardt, and Miriam Gössner.

She took over additional hosting at the Wok World Cup broadcast on ProSieben in March and at the TV total Stock Car Crash Challenge in October 2015.

Starting in 2012, Thomalla became a party member and public supporter of the Christian Democratic Union of Germany (CDU).

[5] In 2023, she declared to have left the party as the conservative CDU turned out to be too "woke" for her in the debate about misconduct allegations against her former partner, Rammstein singer Till Lindemann.

In March 2019, she began dating German football goalkeeper Loris Karius with whom she later moved to Istanbul, Turkey, where he was playing at the time.