Sophia Vitovtovna of Lithuania (Lithuanian: Sofija Vytautaitė, Russian: Софья Витовтовна, romanized: Sofya Vitovtovna; 1371 – 1453) was the grand princess of Moscow as the wife of Vasily I from 1391 to 1425.

On 21 January 1391, while her father was engaged in the Lithuanian Civil War, she married Vasili I of Moscow.

Her father supported Vasili's claim to the throne, which was disputed by his uncle, Yuri of Zvenigorod.

Sophia was buried in the Ascension Convent; the sarcophagus was moved in 1929 to the Cathedral of the Archangel by Soviet authorities.

[2] She and Vasili I had at least nine children, five boys (of which only one survived to mature adulthood) and four girls: