Sophie of Mecklenburg, also spelled Sophia (18 December 1481 – 12 July 1503 in Torgau) was a German noblewoman.

She was a Duchess of Mecklenburg by birth and by marriage Electoral Princess of Saxony.

Her bronze grave plate was crafted by Peter Vischer the Elder in his workshop in Nuremberg, after a design by Jacopo de' Barbari.

It was dedicated to Saint Anne and the Fourteen Holy Helpers, and was inaugurated on 18 July 1505.

[1] Another painting by Cranach, a compact representation of the Fourteen Holy Helpers, remained in Torgau, and is now placed behind her grave.