Sophonisba, or Hannibal's Overthrow is a 1675 tragedy by the English writer Nathaniel Lee.

It was first performed by the King's Company at Drury Lane with a cast that included Michael Mohun as Hannibal, Marmaduke Watson as Maherbal, Edward Kynaston as Scipio, William Wintershall as Lelius, Charles Hart as Massinissa, Thomas Clark as Massina.

It features Mohun as Hannibal, Nicholas Burt as Maherbal, Wintershall as Bomilcar, Kynaston as Scipio, Edward Lydall as Lelius, Watson as Varro, Hart as Massinisa, Martin Powell as Trebellius, Clark as Massina, Philip Griffin as Menander, Elizabeth Cox as Sophonisba, Elizabeth Boutell as Rosalinda, Mary Knep as Aglave and Katherine Corey as Cumana.

[3] Lee dedicated the published version to the Duchess of Portsmouth, mistress of Charles II.

It also contained a prologue written by John Dryden at the time of the Oxford performances.