She first appears in Green Lantern Corps: Recharge #1 (November 2005), and was created by writers Geoff Johns, Dave Gibbons, and artist Patrick Gleason.

Sinestro, unbeknownst to his superiors, the Guardians of the Universe who recruit members of and administrate the Green Lantern Corps, used his power ring to enslave his people and rule over them as a dictator.

Rather, Tui was seen as a monster by her own people for allying herself with the Corps, even after she eventually gave her life in the line of duty, and is known among the Korugarans as "The Lost".

When Tarkus Whin, the Green Lantern of Space Sector 1417 (of which Korugar is also a part) was killed on his first day as a Green Lantern after Star 196 collapsed into a black hole, his ring sought out a replacement and found Dr. Natu in the middle of delicate neurosurgery on her home planet, Korugar.

She uses it to conjure an elaborate medical apparatus that saved him, though her comrades in the operating room felt that by accepting the ring, she has damned herself.

Fellow Lanterns Kyle Rayner and Guy Gardner rescue Natu and convince her to stay in the Corps.

[3] Natu, Rayner, and Gardner rendezvous with Corps trainer Kilowog and new recruits Vath Sarn and Isamot Kol.

After seeking advice from Mogo, she elects to return to her homeworld and continue her work as a surgeon along with her Green Lantern duties.

However, after using her ring to surgically save a dying homeless man, the poor underclass of Korugar begins coming to her for medical help.

While happy with this development, Natu is uncomfortable when the people begin championing her as their savior and using her as a symbol for revolution against the planet's elite.

[9] Soranik Natu came to Earth to aid her fellow Green Lanterns participating in the events of the Sinestro Corps War.

[10] She acts as field medic for the Corps during the battle in New York City, saving Guy Gardner when he was infected by the sentient virus Despotellis.

Natu injects him with a syringe containing Leezle Pon, a fellow Corps member and smallpox virus.

Shortly after her birth, Sinestro came to the conclusion that the disorganized and chaotic world of Korugar was not the kind of place that he wanted to raise his daughter and began his crusade to bring order to his people by force with his powers as a Green Lantern.

The mark, shaped like his family's coat of arms (the two downward pointed triangles underneath her left eye), contained a micro transmitter that would enable him to find her easily from then on.

Sinestro concludes his story by telling Soranik that he was proud of her and everything she has accomplished, namely succeeding where he failed by bringing order to Korugar.

[14] Realizing that Sinestro was telling the truth, Soranik later tries to remove the mark on her face using a laser construct created by her ring to destroy the evidence of her relationship with her despotic father but fails, thus leaving her a bitter reminder.

[15] In the "Blackest Night" storyline, while on their way back to Oa, Soranik and Iolande meet up with Guy Gardner and Kyle Rayner.

[16] As the battle rages on, Soranik and Iolande make a stand in the Oan infirmary, desperately trying to defend the wounded from the Black Lanterns' assault.

[21] In the "Brightest Day" storyline, the follow-up "Blackest Night", Jade, acknowledging that Kyle moved on following her death, and is in love with Natu, says she will not interfere with their relationship.

During the 2011 storyline "War of the Green Lanterns" storyline, Natu, like the rest of the Corps, falls under the control of Krona after he infects the central power battery with Parallax, although Hal, John, Kyle and Guy are able to resist Krona's influence due to their past conflict with Parallax long enough to don new rings.

[30] She is subsequently partnered with new recruit Nax of the Naidroth Collective, a fellow surgeon with a unique gift that she calls "psychic vivisection" – the ability to pull bodies apart and put them back together again, which is agonizingly painful for those not sedated.