Some ancient documents talk about alluvial lands near river Po owned from the Bishop after concession of Holy Roman Emperors Charles III the Fat in 973 and Henry VI in 1195.

After a big flood that interested the area from Casalmaggiore to Fossacaprara and moved northwards the river course, the place became an island and then was joined to Parmesan bank.

In 1634 the Germans stationed in Castelnovo di Sotto raided and burned the church of Mezzano Inferiore and devastated the village.

Some old memoirs talk about the battle of Colorno of 1734 for Mantua succession but in fact it took place in Mezzano Inferiore: some cannonballs still lie on the bell tower.

The loss of autonomy and privileges granted till that event, the new taxes introduced from Parma caused a revolt against duke Filippo Borbone.

Mezzani was decorated with the Bronze Medal for Military Valour for its participation in the Italian resistance movement during World War II.