It is the referral hospital for the districts of Amuria, Bukedea, Kaberamaido, Kapelebyong, Katakwi, Kumi, Ngora, Serere and Soroti.

[1] Soroti Hospital is located in the central business district of the city of Soroti, about 102 kilometres (63 mi), by road, northwest of Mbale Regional Referral Hospital, in the city of Mbale.

[3] Soroti Regional Referral Hospital is located about 294 kilometres (183 mi), by road, northeast of Mulago National Referral Hospital, in Kampala, Uganda's capital city.

[6] The hospital is designated as one of the 15 Internship Hospitals in Uganda where graduates of Ugandan medical schools can serve one year of internship under the supervision of qualified specialists and consultants.

[8] Soroti Regional Referral Hospital is governed by a 19-person board, chaired by Dr Charles Vincent Ojoome, effective August 2019.