Nashawn Wade claims that he has loved planes since he was a child, but he has a horrible experience with a typical airline: his dog Dre is classified as a checked baggage instead of a carry-on, he eats a horrible airline meal, his buttocks get stuck in the toilet while he has diarrhea, caused by his meal, during turbulence, and Dre is fatally sucked through a jet engine after a flight attendant accidentally opens the cargo door.

At a cruising altitude of Flight Level 330, it is revealed that he has never left the ground because he learned to fly on computer simulators in prison.

Meanwhile, his cousin Muggsey sets up a miniature casino and strip joint in one of the areas of the plane (as seen in the workprint and unrated versions of the film), and Nashawn's ex-girlfriend, Giselle is on board and less than happy to see him.

Meanwhile, the Hunkee family, the only Caucasian passengers on board, must also deal with their own problems; Elvis' daughter Heather is turning 18 and plans to use her newfound freedom by drinking and having sex, his son has transformed from an exact duplicate of him to a stereotypical wigger, and his wife is suddenly addicted to black men after viewing pictures in a pornographic magazine.

He claims that he and his ex-girlfriend are back together and are taking their relationship slow this time around, his cousin Muggsey has started a strip club and gambling casino located in another airplane similar to the club in Nashawn's plane, Elvis has begun a sexual relationship with Jamiqua, and his son Billy has become a major music video director but has disappeared shortly after filming a Michael Jackson video.

In its opening weekend, the film made $5,648,486 in the domestic box office, ranking number five behind Shrek 2, The Day After Tomorrow, Troy, and Raising Helen.

[3] In an interview on the podcast WTF with Marc Maron, Hart said that the poor box office turnout was partly due to bootlegging, which had apparently begun three months before the film was released in theaters.

[8] Stephen Holden of The New York Times says in his review: "This hectic farce, which pushes every envelope, is so broad and relentlessly raunchy that it makes a spoof like Airplane seem as demure as a vintage drawing-room comedy.

Club's Nathan Rabin criticized the film for having stereotypical characters and humor made up of "desperate half-gags further botched by clumsy camera work and atrocious timing.

"[11] Wesley Morris of The Boston Globe gave the film credit for delivering a couple funny gags but was offset by "embarrassing bathroom jokes and witless raunch".