South Africa competed at the 2010 Summer Youth Olympics, the inaugural Youth Olympic Games, held in Singapore from 14 August to 26 August 2010.

The nation was represented by the South Africa Olympic Committee, which sent a total of sixty-two athletes to compete in thirteen sports.

The flagbearer at the opening ceremony for the nation was fencer Wanda Matshaya.

[1] The following South African athletes won medals at the Games, all dates shown are August 2010.

In the results sections below, medallists' names are emboldened.