South Africa secured a quota place in the men's W1, event by virtue of their result at the 2024 Africa–Oceania Qualification Tournament in Dubai, United Arab Emirates.

South African track and field athletes achieved quota places for the following events based on their results at the 2023 World Championships, 2024 World Championships, or through high performance allocation, as long as they meet the minimum entry standard (MES).

[2] South Africa entered one para-equestrianist into the Paralympic equestrian competition, by virtue of the nations individual final world para dressage rankings.

South Africa entered five swimmers (two men and three women), through the results at the 2023 World Para Swimming Championships after finishing in the top two places in Paralympic class disciplines; and by achieving the Minimum Qualification Standard (MQS) allocation slots.

[3] South Africa entered five players into the Paralympics by virtue of the gold medal results at the 2023 African Para Games in Accra, Ghana.