[2] In March 2022, the tour itinerary was updated, with matches moved from Bangalore and Nagpur to Cuttack and Visakhapatnam.

[6] Ahead of the first T20I match, India's captain KL Rahul was ruled out the series due to a right groin injury.

[9] South Africa won the opening T20I match by seven wickets,[10] denying India a chance to break the record of most consecutive team wins in the format.

[12] India then won the third T20I by 48 runs,[13] to give Rishabh Pant his first win as the captain of the Indian team.

[16] KL Rahul and Kuldeep Yadav were ruled out of India's squad due to a groin and hand injury respectively.