Students at GSSM select from a wide range of STEM courses during their two years on campus.

[3] Students can conduct semester or year-long scientific investigations,[4] in addition to the required Summer Program for Research Interns (SPRI).

[5] During SPRI, students conduct six weeks of mentored scientific, business or economics research at university or corporate R&D labs across South Carolina or in locations across the United States and other countries.

Beyond the education provided to students in residence, the school delivers outreach programs[8] for middle schoolers in satellite locations statewide, as well as for rising 8th through 10th graders at its annual, residential summer program, GoSciTech.

[9] In 2010, two new wings were added: the Academic Wing, containing classrooms and laboratories, and the Student Activities Center, which includes an engineering projects center and also a gym, weight room, game room, and kitchen.

[10] Admission to GSSM is by application and open to any resident of South Carolina in their sophomore year of high school.

For the 2020–2021 school year, submission of a PSAT, SAT, or ACT score was optional.

RLCs are full-time staff members that live on campus to assist the students.

In 2018, the boys' soccer team won the South Carolina division 1A state championship.

In November 2018, the girls' volleyball team won the South Carolina division 1A state championship.