Just south of Virginia Acres Park, they intersect SC 19 (Whiskey Road).

They pass Citizens Park and leave the city limits of Aiken before they curve to the north-northeast.

The two highways curve to the southeast and split north of Aiken State Park.

Then, it crosses over Dean Swamp Creek and curves to the east-northeast and enters Wagener.

Just northeast of Wagener–Salley High School, it intersects SC 113 (Main Street South).

After it leaves the city limits, it travels along the eastern edge of Columbia Metropolitan Airport and crosses Savana Branch.

At Boston Avenue, east of the high school, it begins traveling along the Springdale–Cayce line.

Glenn Street marks the point where the highway enters West Columbia proper.

It crashed through the airport boundary fence then coming to rest onto an embankment near 2860 Edmund Highway, killing four people.

In 1942, its southern terminus was extended with US 1 and SC 19 through Aiken, then by itself to end in Kathwood, which is just northwest of Jackson.