South Carolina Highway 55 (SC 55) is a 20.990-mile (33.780 km) primary state highway in the U.S. state of South Carolina.

It connects the city of Clover to Blacksburg, Rock Hill, and Charlotte, North Carolina.

SC 55 is a rural two-lane highway, with a median in and around Clover; between Clover and Lake Wylie, it is also paralleled by a major transmission line.

Travelers to and from Charlotte would connect through SC 557, just east of Clover.

The current SC 55 was established in 1931 as a new primary routing from Kings Creek to Lake Wylie.