South Dakota's 22nd legislative district is one of 35 districts in the South Dakota Legislature.

In the Senate, it has been represented by Republican David Wheeler since 2021.

[1] In the House, it has been represented by Republicans Roger D. Chase since 2017 and Lynn Schneider since 2020.

[2] The district contains Beadle, Clark, and Spink counties in southern South Dakota.

Its largest city is Huron.