Before the 2016–17 school year, most of the Coyotes' athletic events were held in the multi-purpose DakotaDome, located in Vermillion, South Dakota.

Football and basketball were the main events for the venue, followed by volleyball, indoor track, and swimming.

A primary member of the Summit League, the University of South Dakota sponsors teams in seven men's and ten women's NCAA sanctioned sports.

[2] The Coyote women's basketball team made its first NCAA Division 1 Tournament appearance in 2014.

The Coyote women's basketball team won the WNIT Championship over Florida Gulf Coast in 2016.