After leaving the city limits of Pollock, the highway curves to the northeast and crosses over part of Lake Pocasse.

After an intersection with SD 271 (319th Avenue), the highway enters the west-central part of McPherson County.

They skirt along the northern edge of the Highway 10 State Public Shooting Area.

They travel north of the Moscow State Public Shooting Area and then curve to the southeast.

SD 10 continues to the east and, at an intersection with 373rd Avenue, enters the northwestern part of Brown County.

SD 10 travels just north of Willow Creek Lake and crosses over Elm River before it intersects US 281 (386th Avenue) southwest of Barnard.

The two highways travel concurrently to the east for approximately 2 miles (3.2 km), splitting at 406th Avenue.

At an intersection with the southern terminus of 412th Avenue, the highway enters the west-central part of Marshall County.

Just south-southeast of the appropriately-named Lake City, the highway begins a concurrency with SD 25.

The highway curves back to the east and enters the northwestern part of Roberts County.

It travels just north of the Coteau des Prairies Hospital and then crosses over some railroad tracks of BNSF Railway.

After a curve to the south and then to the southeast, it reaches its eastern terminus at the Minnesota state line.