East of an intersection with the northern terminus of Jackson Street, SD 28 skirts along the southern part of Mud Lake.

East of this intersection, it crosses over some railroad tracks of BNSF Railway and leaves the city limits of Willow Lake.

East of an intersection with the southern terminus of CR 12 (432nd Avenue), the highway begins a concurrency with SD 25.

The two state highways travel due south for approximately 3 miles (4.8 km).

An intersection with the southern terminus of South Railway Street leads to the business district.

East of an intersection with the southern terminus of South William Street, the highway leaves the city limits of Bryant.

Just east of this intersection, SD 28 enters the northern part of Lake Norden.

An intersection with the northern terminus of Burlington Street leads to the South Dakota Amateur Baseball Hall of Fame.

Just east of this intersection, the highway begins a curve to the east-southeast and leaves the city limits of Lake Norden.

The two highways travel concurrently to the north for approximately 1 mile (1.6 km), while the roadway continues to the east as 193rd Street.

Just west of 464th Avenue, it crosses over the Big Sioux River and curves to a nearly due-east direction.

Just east of Sorenson Road, it passes a sewage disposal pond and enters the west-central part of Estelline.

An intersection with 6th Street leads to Beckman Field and Estelline Elementary & High School.

East of Eastwood Drive, the highway leaves the city limits of Estelline.

The only part of SD 28 that is included as part of the National Highway System, a system of routes determined to be the most important for the nation's economy, mobility and defense, is the small portion concurrent with US 81 near Lake Norden.