South Main Historic District is a national historic district located at Bishopville, Lee County, South Carolina.

It encompasses 11 contributing buildings in a residential section of Bishopville.

They were constructed between about 1880 and 1925, and is the best remaining concentration of historic residential architecture in Bishopville.

The district contains a fine grouping of late-19th and early-20th century residences reflecting the vernacular Queen Anne, Colonial Revival and Bungalow styles.

This article about a property in Lee County, South Carolina on the National Register of Historic Places is a stub.