South Main Street Historic District is a national historic district located at Joplin, Jasper County, Missouri.

The district encompasses eight contributing buildings in a commercial section of Joplin.

It developed between about 1901 and 1960 and includes representative examples of Italianate and Colonial Revival style architecture.

[2] It was listed on the National Register of Historic Places in 2010.

This article about a property in Jasper County, Missouri on the National Register of Historic Places is a stub.