The South Main and South Elm Streets Historic District in Henderson, Kentucky is a historic district which was listed on the National Register of Historic Places in 1992.

[1] It includes all or part of 13 blocks roughly bounded by Washington, Center, S. Green, Jefferson, S. Main and Water Streets, including 125 contributing buildings, four contributing structures, and a contributing site, on about 49 acres (20 ha).

[2] Architects Shopbell & Harris and Benjamin Bosworth Smith designed works in the district.

It includes 125 contributing buildings, four contributing structures, and a contributing site, on 49 acres (20 ha).

This article about a property in Henderson County, Kentucky on the National Register of Historic Places is a stub.