[6][7] The club entered the Victorian Junior Football Association (VJFA) in 1914, finishing fourth on the ladder, before being defeated by Port Melbourne Railway United by 51 points in the grand final.

[8][9][10][11] The club made its second grand final in 1922 after another fourth-placed home-and-away finish, where they lost to North Melbourne Juniors by 22 points.

[20] In the late 1920s, the Districts donated 40 guineas to South Melbourne to stop them from folding, and often provided assistance payments to players when needed.

[a][39][40] South Melbourne Districts joined the Metropolitan Football League (MFL), the successor to the VFL Sub-Districts, when the competition was formed in 1950.

At the end of the 1999 season, South Melbourne Districts left the SFL to join the Victorian Amateur Football Association (VAFA).