The South Plains is a region in northwest Texas, United States, consisting of 24 counties.

While prominent in the area of petroleum production, the South Plains is mainly an agricultural region, producing a great percentage of the nation's cotton and possessing numerous large cattle ranches.

Cotton is the most common crop grown in South Plains region.

[1] In an extended area comprising 31 counties in and near the South Plains, more than a million bales of cotton were harvested in 2005.

This makes the South Plains the world’s largest cotton-producing region.