South Portland Street Synagogue was a former Orthodox Jewish synagogue, that was at 85-89 South Portland Street in the Gorbals area of Glasgow, Scotland, in the United Kingdom.

From its establishment in 1901 until its closure in 1974, it was regarded as the centre of Jewish religious in Glasgow.

[3] At the time of opening, South Portland Street was the largest synagogue in Scotland, with seating for 1,000 people and the option for up to 1,600 people to access services in the Prayer Hall with the opening of folding doors.

[6] The congregation, who worshipped in the Ashkenazi rite, was formed in 1881 in response to the large numbers of Jewish immigrants who were moving to the Gorbals area.

As a result of this immigration, a number of synagogues were established in the Gorbals, of which South Portland Street was the largest.