South Roxana, incorporated in March 1967, is a village in Madison County, Illinois, United States.

[3] South Roxana is bordered to the north and east by the village of Roxana, to the south by a western extension of the city of Edwardsville, and to the west by the village of Hartford.

Illinois Route 111 runs along the western edge of South Roxana, leading north 2 miles (3 km) to Wood River and south 6 miles (10 km) to Pontoon Beach.

Illinois Route 255, a four-lane expressway, passes just east of the village limits, with access from Exits 3 and 5.

[2] At the 2000 census there were 1,888 people, 707 households, and 518 families living in the village.