South Salina Street Downtown Historic District is a historic district in the United States, representing what was the commercial core of in Syracuse, New York from the mid-nineteenth century to the mid-twentieth century.

The vacancy rate in the district is high, and some buildings need extensive rehabilitation.

Recent revitalization plans served as impetus for seeking listing on the National Register of Historic Places.

[2] Among the contributing properties are two the White Memorial Building and the Loew's State Theater, also individually listed on the National Register of Historic Places.

[3] Architects represented in the district include Horatio Nelson White, Archimedes Russell, Charles E. Colton, Joseph Lyman Silsbee, Charles D. Wilsey and Thomas W. Lamb.