Vision Statement: South San Francisco High School will graduate resilient, empathetic, lifelong learners who will become productive, globally conscious citizens with useful skills to contribute to an ever changing society.

The video broadcasting class provides live segments daily through the schools cable network and online.

Science Garage was built at South San Francisco High School with support from a $7.8 million grant from the Genentech Foundation, and opened in late 2017".

[5] The learning space includes picnic tables and benches for students to utilize during lunch as well as a projector and screen for outdoor lessons.

They considered the logo depicting a generalized Native American man in a feathered headdress to be a stereotypical and disrespectful portrayal of indigenous people.

SSFHS Students 4 Change circulated a petition, created an informative video, and presented to the school board prior to its official decision.

Several athletic uniforms and fields often sported “SC” for South City instead of the Native American headdress logo.

Advancement Via Individual Determination (AVID) is an elective program offered at South San Francisco High School.

The purpose of this project is to apply and showcase the skills they have learned over the all their four years of high school and to explore in depth a career field that interests them.

Physical projects can include but are not limited to: cellphone and computer based applications, choreographed dance routines, video interviews/montages/documentaries, and more.

South San Francisco High School offers a variety of sports, including cheerleading, American football, badminton, baseball, basketball, golf, soccer, softball, swimming, tennis, track and field, volleyball, wrestling and cross country.

"[14] After not being held in 2021 due to the COVID pandemic, the tournament returned in 2022 featuring teams from South San Francisco, Woodside, and Hillsdale High Schools.

Notable seasons In 1980 the varsity football team defeated North Monterey County HS, 17–7, to win the Central Coast Section Championship.