The FIBA Women's AfroBasket 2021 Zone 5 Qualifiers marked the first time South Sudan was represented in women's basketball at the international level since gaining independence in 2011 and becoming a FIBA member in 2013.

[2] the team was placed in Zone 5 Group A, with Egypt, Kenya, Rwanda.

South Sudan played its first official international game on 12 July 2021, against the Egyptian team.

[3] In 2023, South Sudan marked history by winning its first international game against Rwanda by a margin of 14 points.

[4] Note: updated through 22 February 2023 Roster for the 2023 Women's Afrobasket qualification.