The South Wayne Historic District is a national historic district that is located in Wayne, Delaware County, Pennsylvania.

[1] This district includes 316 contributing buildings that are located in a residential area of Wayne.

The majority of the dwellings were built between 1881 and 1930 and include notable examples of Shingle Style and Colonial Revival architecture, representing the work of William Lightfoot Price, Horace Trumbauer, and several other architects.

This historic district reflects suburban development in the late-nineteenth century.

It was a major component of a large, planned, railroad commuter suburb called "the Wayne Estates," complementing the northern half of the residential area that is now included in the North Wayne Historic District, and the downtown area of Wayne, which sits between the two residential districts, now the Downtown Wayne Historic District.