It is on the Seaford branch of the East Coastway Line, 53 miles 40 chains (86.1 km) measured from London Bridge via Redhill.

The London, Brighton and South Coast Railway opened the station on 1 September 1906 as Southease and Rodmell Halt, to serve two villages in the Ouse Valley; Southease, 0.5 miles (800 m) to the west, and the slightly larger Rodmell, more than 1 mile (1.6 km) away.

[3] There was a racecourse between the railway line and the River Ouse from the late 1920s to the early 1940s.

There is a level crossing immediately north of the station leading to Itford Farm and the A26 road.

All services at Southease are operated by Southern using Class 377 EMUs.