Southeastern Freight Lines (SEFL) is a privately owned American less than truckload (LTL) trucking company based in Lexington, South Carolina that operates in the Southeastern and Southwestern United States.

[3] Southeastern Freight Lines was founded in 1950 by William T. Cassels in Lexington, South Carolina.

[11] Kentucky operations of Southeastern Freight was established in 2015 with expansions to Lexington, Louisville and Bowling Green.

Transportation internationally includes Canada, Mexico, and the United States Virgin Islands.

[18][19] In 2011, Southeastern Logistics Solutions was launched as a subsidiary of Southeast Freight to provide expedited service and multi-modal transportation.